Molecular Pathology of Lung Diseases (Molecular Pathology by Dani S. Zander, Helmut Popper, Jaishree Jagirdar, Abida

By Dani S. Zander, Helmut Popper, Jaishree Jagirdar, Abida Haque, Roberto Barrios, Philip T. Cagle

Molecular Pathology of Lung ailments, the 1st quantity within the Molecular Pathology Library sequence below the sequence editorship of Philip T. Cagle, MD presents a bridge among scientific pulmonary pathology and simple molecular technological know-how. it's designed to supply a pragmatic disease-based assessment that might be beneficial to pathologists, pulmonologists, thoracic surgeons and different future health care services attracted to lung disease.

The first sections of the quantity give you the reader with basic strategies, terminology and tactics in molecular pathology. the rest of the amount is subdivided into neoplastic and non-neoplastic lung ailments with unique chapters masking the present molecular pathology of particular diseases.

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Activation of growth factor receptors converts Ras from its inactive guanosine diphosphate (GDP)-bound state to its active GTP-bound state. Activated Ras recruits Raf protein–serine/threonine kinase from the cytosol to the plasma membrane where kinases activate Raf. ERK, a member of the MAPK family, is activated by Raf through MAP/ERK kinase (MEK). In turn, the activated ERK phosphorylates and activates multiple other proteins, including other protein kinases. Activated ERK also translocates into the nucleus where it phosphorylates and activates transcription factors including Elk-1.

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