Cigarette Smoke and Oxidative Stress by Barry B. Halliwell, Henrik E. Poulsen

By Barry B. Halliwell, Henrik E. Poulsen

From a public future health standpoint, there's little question that the most very important preventable reasons of ailment around the globe is tobacco smoking. it's also transparent that tobacco smoke incorporates a colossal variety of chemical substances with vital organic efects in illness strategies. Te fuel part of tobacco smoke is oxidizing, the tar section is decreasing, and full smoke is approximately impartial, so its efects on oxidative pressure can be an “antioxidant paradox. ” From a scientifc perspective, we discovered it of curiosity to make a entire ov- view of what we almost immediately learn about oxidative pressure and tobacco smoke, simply because sm- ing is almost immediately the best-known universal linked to oxidative rigidity, and it could possibly function a version for others. To this finish, now we have requested extraordinary researchers from the general public and the personal sectors to guage the current scientifc prestige of their specific region. Authors have been chosen basically as a result of their scientifc advantages. we don't declare that each one the well-described health and wellbeing dangers linked to cigarette smoking stem from oxidative tension, nor may still we. even if, we should be capable of fnd out, and for a few of these healthiness dangers, we will already say. we are hoping this booklet will stimulate extra learn to fnd solutions to the remainder questions. Barry Halliwell and Henrik E. Poulsen Contents 1 Oxidative pressure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Barry B. Halliwell and Henrik E. Poulsen 2 Tobacco Smoke elements Affecting Oxidative rigidity . . . . . . . . . . .

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Extra resources for Cigarette Smoke and Oxidative Stress

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Biochem Biophys Res Commun 122:676–681 Pryor WA, Hales BJ, Premovic PI, Church DF (1983a) The radicals in cigarette tar: their nature and suggested physiological implications. Science 220:425–427 Pryor WA, Prier DG, Church DF (1983b) Electron-spin resonance study of mainstream and sidestream cigarette smoke: nature of the free radicals in gas-phase smoke and in cigarette tar. Environ Health Perspect 47:345–355 Pryor WA, Tamura M, Dooley MM, Premovic P, Hales BJ, Church DF (1983c) Reactive oxy-radicals from cigarette smoke and their physiological effects.

O2–• + 2H+ → H2O2 (2) H2O2 + Fe2+ → •OH + OH– + Fe3+ (3) Superoxide and hydroxyl radicals have been shown to form in aqueous extracts of cigarette smoke (Pryor et al. 1998; Zang et al. 1995). It was also shown that aqueous extracts of TPM produce hydroxyl radicals that can be spin-trapped with 5,5-dimethyl1-pyrroline-N-oxide (DMPO). The hydroxyl radicals arise from the metal mediated decomposition of H2O2, as shown above (Cosgrove et al. 1985; Pryor 1992). The DMPO–superoxide radical adduct is unstable, with a half-life of 80 s at pH 6 and 35 s at pH 8.

Mol Pharmacol 34:829–836 Chapter 2 Tobacco Smoke Constituents Affecting Oxidative Stress Leffingwell JC (1999) Leaf chemistry: basic chemical constituents of tobacco leaf and differences among tobacco types. In: Davis LD, Nielson MT (eds) Tobacco: production, chemistry and technology. Blackwell, London, pp 265–303 Lepoivre M, Flaman JM, Bobe P, Lemaire G, Henry Y (1994) Quenching of the tyrosyl free radical of ribonucleotide reductase by nitric oxide. Relationship to cytostasis induced in tumor cells by cytotoxic macrophages.

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