Biomarkers and Mental Illness: It’s Not All in the Mind by Paul C. Guest

By Paul C. Guest

Employing available language all through, this ebook covers the historical past of psychiatric examine, the present state-of-the paintings in psychiatric perform, the physiological structures plagued by psychiatric health problems, the whole-body nature of those ailments and the effect that this element has on rising biomarker discoveries.

Further, it presents descriptions of the key particular psychiatric problems and the targeted demanding situations in regards to the analysis and therapy of every. The publication concludes with insights into the most recent advancements in handheld biomarker try out units, that can supply diagnostic details in below quarter-hour in point-of-care settings.

This publication investigates the rising use of biomarkers within the learn of psychiatric ailments, a subject matter of substantial significance for a vast variety of individuals together with researchers, clinicians, psychiatrists, college scholars or even these whose lives are affected not directly via a psychiatric affliction. The final class is infrequently trivial, given that a remarkable one in 3 humans around the world exhibit the standards for a minimum of one psychiatric disease at some point soon of their lifetime.

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Additional info for Biomarkers and Mental Illness: It’s Not All in the Mind

Sample text

There are other limitations which makes interpretation of the findings from brain proteomics studies difficult. First, the use of post-mortem material is not ideal as it cannot be collected under standard conditions and it therefore varies in such parameters as differences in the time after death that the material is collected and stored (the post-mortem interval), time and method of storage as well as other variables. Furthermore, virtually all psychiatric patients are likely to have received various medications and suffered co-morbidities (other diseases) throughout their lives up to the time of death.

This means that the patient’s condition may have resulted from physical symptoms. Interestingly, laboratory testing showed the presence of antibodies in the serum against the N-methyl-D-aspartate (NMDA) receptor (a type of excitatory glutamate receptor) in the serum and cerebrospinal fluid of the patient. Based on this, a final diagnosis of anti-NMDA receptor encephalitis (a rare disease) was made and the doctors identified a teratoma of the ovary, which was surgically removed. After treatment with anti-inflammatory drugs the patient slowed a slow improvement, although symptoms such as the speech impediments, loss of concentration and altered personality disorder persisted for several months.

The prodrome stage is identified based on the presence of symptoms such as disturbed thoughts, social isolation and impaired functioning. Some of these features are common during adolescence and the problem of distinguishing a high risk for psychosis from more common adolescent angst has always been a major challenge. At present, diagnosis of schizophrenia is mainly based on the symptoms and signs of psychosis. However, this is likely to occur not at the beginning but What Kinds of Biomarkers Have Been Identified?

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