Bioinformatics: Sequence, Structure and Databanks: A by Des Higgins, Willie Taylor

By Des Higgins, Willie Taylor

This quantity covers functional vital themes within the research of protein sequences and constructions. It comprises evaluating amino acid sequences to constructions evaluating buildings to one another, looking details on whole protein households in addition to looking out with unmarried sequences, how one can use the web and the way to establish and use the SRS molecular biology database administration procedure. eventually, there are chapters on a number of series alignment and protein secondary constitution prediction. This publication could be valuable to occasional clients of those suggestions in addition to skilled execs or researchers.

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Acad. Set USA, 89,12098. 12 THREADING METHODS FOR PROTEIN STRUCTURE PREDICTION 3. , and Schneider, R. (1993). Prediction of protein structure by evaluation of sequence-structure fitness. J. Mol. , 232, 805. 4. , and Argos, P. (1994). Recognition of distantly related proteins through energy calculations. Proteins: Struct, Funct. , 19, 132. 5. , Johnson, M. , and Blundell, T. L (1992). Environment-specific amino-acid substitution tables—tertiary templates and prediction of protein folds. , 1, 216.

An alignment 19 MARK S. JOHNSON AND JUKKA V. LEHTONEN 3 algorithm is used to give the best 'sequence alignment' based on the structural features that have been supplied. g. rigid-body). g. Monte Carlo simulations (11), simulated annealing (7), double dynamic programming (10), genetic algorithms. the structures can subsequently be superposed according to the matches in the alignment, but a single global superposition may be meaningless when large movements, such as domain movements, have taken place.

Proc. Nail. Acad. Set USA, 89,12098. 12 THREADING METHODS FOR PROTEIN STRUCTURE PREDICTION 3. , and Schneider, R. (1993). Prediction of protein structure by evaluation of sequence-structure fitness. J. Mol. , 232, 805. 4. , and Argos, P. (1994). Recognition of distantly related proteins through energy calculations. Proteins: Struct, Funct. , 19, 132. 5. , Johnson, M. , and Blundell, T. L (1992). Environment-specific amino-acid substitution tables—tertiary templates and prediction of protein folds.

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