Bioinformatics for Geneticists: A Bioinformatics Primer for

Praise from the reviews:

"Without reservation, I recommend this article because the top source i have encountered that well introduces and summarizes many issues i have realized via years of experience.  The gemstones of fact present in this booklet will serve good those that desire to observe bioinformatics of their day-by-day paintings, in addition to support them suggest others during this capacity." CIRCGENETICS

"This ebook may possibly particularly support to get geneticists and bioinformaticians on 'speaking-terms'... contains a few crucial studying for nearly any one operating within the box of molecular genetics." ecu magazine OF HUMAN GENETICS 

"... a good resource... this publication should still make sure that any researcher's ability base is maintained." GENETICAL study

“… the best to be had and such a lot available texts on bioinformatics and genetics within the postgenome age… The writing is apparent, with succinct subsections inside each one chapter….Without reservation, I advise this article because the most sensible source I’ve encountered that smartly introduces and summarizes many issues I’ve discovered via years of expertise. The gemstones of fact present in this ebook will serve good those that desire to follow bioinformatics of their day-by-day paintings, in addition to support them propose others during this capacity.”  stream: CARDIOVASCULAR GENETICS

a completely revised model of the winning First version, this one-stop reference booklet allows all geneticists to enhance the potency in their study.

The examine of human genetics is stepping into a hard new period. New applied sciences and information assets similar to the HapMap are permitting genome-wide reports, that can probably determine commonest genetic determinants of human overall healthiness, disorder and drug reaction. With those great new information assets to hand, greater than ever care is needed of their use. confronted with the sheer quantity of genetics and genomic information, bioinformatics is key to prevent drowning actual sign in noise. contemplating those demanding situations, Bioinformatics for Geneticists, moment Edition works at a number of degrees: to begin with, for the occasional consumer who easily desires to extract or examine particular info; secondly, on the point of the complicated consumer offering factors of the way and why a device works and the way it may be used to maximum impact. eventually specialists from fields allied to genetics supply perception into the simplest genomics instruments and knowledge to augment a genetic test.

Hallmark positive factors of the second one Edition:

  • Illustrates the worth of bioinformatics as a always evolving road into novel methods to review genetics
  • The merely publication particularly addressing the bioinformatics wishes of geneticists
  • More than 50% of chapters are thoroughly new contributions
  • Dramatically revised content material in middle parts of gene and genomic characterisation, pathway research, SNP practical research and statistical genetics
  • Focused on freely to be had instruments and web-based ways to bioinformatics research, compatible for newcomers and skilled researchers alike

Bioinformatics for Geneticists, moment Edition describes the foremost bioinformatics and genetic research approaches which are had to determine human genetic determinants. The ebook relies upon the mixed functional adventure of area specialists from educational and business study environments and is of curiosity to a huge viewers, together with scholars, researchers and clinicians operating within the human genetics domain.Content:
Chapter 1 Bioinformatics demanding situations for the Geneticist (pages 1–16): Michael R. Barnes
Chapter 2 dealing with and Manipulating Genetic facts (pages 17–31): Karl W. Broman and Simon C. Heath
Chapter three The HapMap – A Haplotype Map of the Human Genome (pages 33–58): Ellen M. Brown and Bryan J. Barratt
Chapter four Assembling a View of the Human Genome (pages 59–84): Colin A. M. Semple
Chapter five discovering, Delineating and Analysing Genes (pages 85–104): Christopher Southan and Michael R. Barnes
Chapter 6 Comparative Genomics (pages 105–144): Martin S. Taylor and Richard R. Copley
Chapter 7 picking Mutations in unmarried Gene problems (pages 145–164): David P. Kelsell, Diana Blaydon and Charles A. Mein
Chapter eight From Genome experiment to perpetrator Gene (pages 165–184): Ian C. Gray
Chapter nine Integrating Genetics, Genomics and Epigenomics to spot illness Genes (pages 185–215): Michael R. Barnes
Chapter 10 instruments for Statistical Genetics (pages 217–246): Aruna Bansal, Charlotte Vignal and Ralph McGinnis
Chapter eleven Predictive useful research of Polymorphisms: an outline (pages 247–280): Mary Plumpton and Michael R. Barnes
Chapter 12 sensible in Silico research of Gene Regulatory Polymorphism (pages 281–309): Chaolin Zhang, Xiaoyue Zhao and Michael Q. Zhang
Chapter thirteen Amino?Acid homes and outcomes of Substitutions (pages 311–342): Matthew J. Betts and Robert B. Russell
Chapter 14 Non?Coding RNA Bioinformatics (pages 343–368): James R. Brown, Steve Deharo, Barry Dancis, Michael R. Barnes and Philippe Sanseau
Chapter 15 What are Microarrays? (pages 369–387): Catherine A. Ball and Gavin Sherlock
Chapter sixteen Combining Quantitative Trait and Gene?Expression information (pages 389–411): Elissa J. Chesler
Chapter 17 Bioinformatics and melanoma Genetics (pages 413–445): Joel Greshock
Chapter 18 Needle in a Haystack? facing 500 000 SNP Genome Scans (pages 447–493): Michael R. Barnes and Paul S. Derwent
Chapter 19 A Bioinformatics standpoint on Genetics in Drug Discovery and improvement (pages 495–528): Christopher Southan, Magnus Ulvsback and Michael R. Barnes

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Additional info for Bioinformatics for Geneticists: A Bioinformatics Primer for the Analysis of Genetic Data, Second Edition

Sample text

These regions were re-sequenced in 48 unrelated subjects OTE/SPH JWBK136-03 OTE/SPH February 16, 2007 38 15:13 Char Count= 0 CH 3 THE HapMap – A HAPLOTYPE MAP OF THE HUMAN GENOME (16 YRI, 16 CEU, eight CHB and eight JPT), and genotyping was attempted for all SNPs whether novel or publicly available in dbSNP. The genotyping was conducted as a multicentre, international effort using a range of technology platforms. The target of one SNP per 5 kb was reached in March 2005 (one SNP per 279 bp was achieved in the ENCODE regions), and a final phase I data freeze made available in June 2005 (public release no.

1 Historical background The unveiling of the first draft of the human genome in June 2000 (Yamey, 2000) enabled a rapid acceleration in research aimed at identifying the genetic variation Bioinformatics for Geneticists: A bioinformatics primer for the analysis of genetic data, Second Edition. Edited by M. R. Barnes © 2007 John Wiley & Sons, Ltd. ISBN 978-0-470-02619-9 (HB) ISBN 978-0-470-02620-5 (PB) OTE/SPH JWBK136-03 OTE/SPH February 16, 2007 36 15:13 Char Count= 0 CH 3 THE HapMap – A HAPLOTYPE MAP OF THE HUMAN GENOME underlying human traits.

Nat Rev Genet 6(2), 109–118. Woodcock, J. (2005). Pharmacogenetics: on the road to ‘personalized medicine’. FDA Consum 39(6), 44. OTE/SPH OTE/SPH JWBK136-02 February 16, 2007 15:10 Char Count= 0 2 Managing and Manipulating Genetic Data Karl W. Broman1 and Simon C. 1 Introduction Geneticists must learn to program: for efficiency, to avoid introducing errors into data, and to make simple what would otherwise be unfeasible. If a geneticist were to learn just one programming language, Perl would be an excellent choice; it is especially valuable for the manipulation of text files, which are the input and output of most statistical genetic software.

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