By Dharam Agarwal, Helmut K. Seitz
This quantity, in keeping with shows from the symposium at the health and wellbeing results of alcohol held in Titisee, Germany, examines the actual and mental outcomes of alcohol use and abuse, and considers environmental and ethnic elements that bring about dependancy and dependence. Discusses epidemiological experiences that convey the impression of sunshine to reasonable consumption of alcoholic drinks on heart illness! that includes contributions from approximately 60 the world over well-known and revered authors, and over 2900 references for extra research of the topic, Alcohol in wellbeing and fitness and affliction ·analyzes biochemical, pharmacogenetic, and pathologic disturbances that keep on with acute and persistent ingestion of alcohol ·describes issues that come up from social, organic, and environmental components ·examines alcohol metabolic genes and their function in alcohol sensitivity, ingesting behavior, and dependence ·spotlights hepatic and dietary issues linked to alcoholism ·considers the connection of alcohol to melanoma ·debates the French paradox ·and extra! overlaying a large number of disciplines, together with molecular biochemistry, genetics, epidemiology, pathophysiology, neurobiology, and cardiology, Alcohol in overall healthiness and sickness is a serious reference for dependancy psychiatrists, neuropsychopharmacologists, psychologists, geneticists, toxicologists, biochemists, environmental and public health and wellbeing scientists, well-being coverage makers, social staff, counselors, and graduate and scientific tuition scholars in those disciplines.
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Extra info for Alcohol in Health and Disease
Hepatology 31:984–989, 2000. C-C Chen, R-B Lu, Y-C Chen, M-F Wang, Y-C Chang, T-K Li, S-J Yin. Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism. Am J Hum Genet 65:795–807, 1999. M Osier, AJ Pakstis, JR Kidd, J-F Lee, S-J Yin, H-C Ko, HJ Edenberg, R-B Lu, KK Kidd. Linkage disequilibrium at the ADH2 and ADH3 loci and risk of alcoholism. Am J Hum Genet 63:1147–1157, 1999. K Edman, W Maret. Alcohol dehydrogenase genes: restriction fragment length 24 72.
Hepatology 23:234–239, 1996. M Matsumoto, H Takahashi, K Maruyama, S Higuchi, S Matsushita, T Muramatsu, K Okuyama, A Yokoyama, M Nakano, H Ishii. Genotypes of alcohol-metabolizing enzymes and the risk for alcoholic chronic pancreatitis in Japanese alcoholics. Alcohol Clin Exp Res 20:289A–292A, 1996. Y-C Chao, T-H Young, H-S Tang, C-T Hsu. Alcoholism and alcoholic organ damage and genetic polymorphisms of alcohol metabolizing enzymes in Chinese patients. Hepatology 25:112–117, 1997. Y Maezawa, M Yamauchi, Y Searashi, K Takeda, Y Mizuhara, T Kimura, G Toda, H Suzuki, S Sakurai.
These association studies illustrate some of the difficulties that must be overcome. Although large-scale studies with linkage techniques and microsatellite markers have yielded QTLs in rats and mice, this has not yet been a route to discovery of alcohol sensitivity genes in humans. Investigation of the serotonin transporter gene (5-HTTLPR) appears to have arisen from the probable involve- 42 Whitfield ment of serotonin systems in impulsive or violent behavior, and from the existence of a deletion/insertion variant that affects gene transcription and transporter expression.