Acquired Neuromuscular Disorders: Pathogenesis, Diagnosis by Corrado Angelini

By Corrado Angelini

This booklet offers state-of-the-art info at the pathogenesis, analysis, and therapy of a variety of inflammatory, autoimmune, and idiopathic neuromuscular issues. the hole part discusses the differential prognosis of bought myopathies according to scientific, electrophysiological, muscle biopsy, and serological standards, with distinctive concentrate on the position of electromyography and antibody checking out. all the appropriate scientific entities is then mentioned intimately, the insurance together with, for instance, myasthenia gravis, polymyositis, immune-mediated neuropathies, multifocal motor neuropathies, amyotrophic lateral sclerosis, paraneoplastic neuropathies, and diabetic polyneuropathy. transparent assistance is equipped on at the moment to be had remedies, with descriptions of the newest advances in physiotherapy, drug treatment, and respiration care. different positive aspects of this clinically orientated publication are the inclusion of many illustrative case displays and contributions by means of overseas authors from major centers.

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Extra resources for Acquired Neuromuscular Disorders: Pathogenesis, Diagnosis and Treatment

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1 L. Santoro and F. Manganelli Muscular Dystrophies The most frequent muscular dystrophies are the dystrophinopathies, Duchenne muscular dystrophy (DMD), and Becker muscular dystrophy (BMD). The diagnostic procedure, after the clinical evaluation, can be addressed with genetic testing, particularly when there is a positive family history or in some cases on muscle biopsy. Therefore, the EMG examination may be helpful in sporadic cases when clinical and biochemical data are equivocal. In these cases, needle EMG can reveal increased insertional activity, some sparse fibrillation potentials, and short, small, polyphasic MUPs with early recruitment.

Elsevier, Philadelphia, pp 65–75 5. AAEM Quality Assurance Committee (2001) American Association of Electrodiagnostic Medicine. Literature review of the usefulness of repetitive nerve stimulation and single fiber EMG in the electrodiagnostic evaluation of patients with suspected myasthenia gravis or Lambert-Eaton myasthenic syndrome. Muscle Nerve 24:1239–1247 6. Howard JF Jr (2013) Electrodiagnosis of disorders of neuromuscular transmission. Phys Med Rehabil Clin N Am 24:169–192 7. Ertaş M, Baslo MB, Yildiz N, Yazici J, Oge AE (2000) Concentric needle electrode for neuromuscular jitter analysis.

Ann Rheum Dis 71:993–996 75. Betteridge ZE, Gunawardena H, Chinoy H et al (2009) Clinical and human leucocyte antigen class II haplotype associations of autoantibodies to small ubiquitin-like modifier enzyme, a dermatomyositis-specific autoantigen target, in UK Caucasian adult-onset myositis. Ann Rheum Dis 68:1621–1625 76. Dalakas MC, Illa I, Gallardo E, Juarez C (1997) Inclusion body myositis and paraproteinemia: incidence and immunopathologic correlations. Ann Neurol 41:100–104 77. Benjamin Larman H, Salajegheh M, Nazareno R et al (2013) Cytosolic 5′-nucleotidase 1A autoimmunity in sporadic inclusion body myositis.

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