A Short History of Medical Genetics by Peter S. Harper

By Peter S. Harper

An eminent geneticist, veteran writer, OMMG sequence Editor, and famous archivist, Peter Harper provides a full of life account of the way our principles and information approximately human genetics have built over the last century from the point of view of somebody contained in the box with a deep curiosity in its old facets. Dr. Harper has researched the historical past of genetics and has had own touch with a bunch of key figures whose stories and reports expand again 50 years, and he has interviewed and recorded conversations with a lot of those very important geneticists. hence, instead of being a traditional background, this publication transmits the essence of the tips and the folks concerned and the way they interacted in advancing- and infrequently retarding- the sphere. From the origins of human genetics; in the course of the contributions of Darwin, Mendel, and different giants; the identity of the 1st human chromosome abnormalities; and up during the crowning glory of the Human Genome venture, this Short History is written within the author's attribute transparent and private type, which appeals to geneticists and to all these attracted to the tale of human genetics.

Show description

Read or Download A Short History of Medical Genetics PDF

Similar special topics books

Covenant of Care: Newark Beth Israel And the Jewish Hospital in America

The place have been you born? have been you born on the Beth? Many millions of Americans-Jewish and non-Jewish-were born at a sanatorium bearing the superstar of David and named Beth Israel, Mount Sinai, or Montefiore. within the usa, wellbeing and fitness care has been certain heavily to the spiritual impulse. Newark Beth Israel medical institution is a distinctive smooth clinical establishment in New Jersey whose historical past opens a window on American healthiness care, the immigrant event, and concrete lifestyles.

Death and Desease in the Ancient City

This leading edge quantity attracts on fresh learn in archaeology, old background and the historical past of drugs to debate how humans within the historic international understood and handled sickness and demise within the city atmosphere.

Shock Therapy: A History of Electroconvulsive Treatment in Mental Illness

Surprise remedy is making a return this day within the remedy of great psychological sickness. regardless of its reemergence as a secure and potent psychiatric instrument, notwithstanding, it is still shrouded by means of a longstanding unfavorable public photograph, no longer least as a result of movies comparable to the vintage One Flew over the Cuckoo's Nest, the place the inmate of a psychiatric health facility (played through Jack Nicholson) is subjected to electro-shock to scale back his rebellious habit.

Pioneers in Plastic Surgery

This publication is a set of brief money owed of the lives and works of surgeons who started to use recommendations within the 19th and 20th centuries that have been to shape the foundation of reconstructive and plastic surgery and provides upward thrust to the strong point of cosmetic surgery. Descriptions of the problematic and novel surgical operations undertaken by way of those pioneers are integrated, however the emphasis is certainly on tales of broadly various and engaging characters, from the unusual or eccentric, resembling Hippolyte Morestin, to the intense or formidable and some, akin to the Dutchman Johannes Esser and the mythical Sir Howard Gillies, who have been entire in different fields, together with enterprise, activity and artwork.

Extra info for A Short History of Medical Genetics

Example text

Notwithstanding this, I was never convinced of a peculiarity in my vision, till I accidentally observed the colour of the flower of the Geranium zonale by candle-light, in the Autumn of 1792. The flower was pink, but appeared F I G U R E 1–4 John Dalton (1766–1844), English scientist and describer of red-green color blindness in himself and his family. ) Before Mendel to me almost an exact sky-blue by day; in candle-light, however, it was astonishingly changed, not having then any blue in it, but being what I called red, a colour which forms a striking contrast to blue.

Thus Lamarck’s ideas have considerable importance in the history of human genetics, regardless of whether or not they were “wrong,” and later developments in “Mendelian” genetics need to be seen against a persistent background of sympathy and support for the general principle that environmentally produced characters are capable of being transmitted to future generations, despite all the evidence against it. 37 38 THE FOUNDATIONS OF HUMAN AND MEDICAL GENETICS Genetics and the Origin of Species The first half of the 19th century was a barren time for scientific philosophy in relation to the mechanisms underlying heredity.

This concept is highly relevant to medical genetics today, and indeed it is almost taken for granted. It underlies our understanding of cancer, notably the “two-hit hypothesis” of familial tumors, and of many developmental and chromosomal disorders. Weismann set out his views clearly and concisely in two essays: the first, “On Heredity,” formed an inaugural lecture at the University of Freiburg in 1883; the second, “The Continuity of the Germ-plasm as the Foundation of a Theory of Heredity,” gave more detail and was based on an 1885 lecture.

Download PDF sample

Rated 4.24 of 5 – based on 32 votes